Title:The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer
Volume: 24
Issue: 39
Author(s): Seyed Mostafa Parizadeh, Reza Jafarzadeh-Esfehani, Amir Avan*, Maryam Ghandehari, Fatemeh Goldani and Seyed Mohammadreza Parizadeh
Affiliation:
- Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad,Iran
Keywords:
Gastric cancer, tissue mirna, Helicobacter pylori, normal flora, miRNA, gastric mucosa.
Abstract: Gastric cancer (GC) has a high mortality rate with a poor 5-year survival. Helicobacter pylori (H. pylori)
is present as part of the normal flora of stomach. It is found in the gastric mucosa of more than half of the
world population. This bacterium is involved in developing H. pylori-induced GC due to the regulation of different
micro ribonucleic acid (miRNA or miR). miRNAs are small noncoding RNAs and are recognized as prognostic
biomarkers for GC that may control gene expression. miRNAs may function as tumor suppressors, or oncogenes.
In this review, we evaluated studies that investigated the ectopic expression of miRNAs in the prognosis of
H. pylori positive and negative GC.
