Title:Recent Progress in Polynuclear Ruthenium Complex-Based DNA Binders/Structural Probes and Anticancer Agents
Volume: 27
Issue: 22
关键词:
钌，DNA，DNA结构探针，细胞毒性，结合模式，顺铂类药物，抗癌药物。
摘要: Ruthenium complexes have stood out by several mononuclear complexes which have entered
into clinical trials, such as imidazolium [trans-RuCl4(1H-imidazole)(DMSO-S)] (NAMI-A) and
([Ru(II)(4,4'-dimethyl-2,2'-bipyridine)2-(2(2'-,2'':5'',2'''-terthiophene)-imidazo[4,5-f] [1,10]phenanthroline)]
2+) (TLD-1433), opening a new avenue for developing promising ruthenium-based anticancer
drugs alternative to Cisplatin. Polynuclear ruthenium complexes were reported to exhibit synergistic
and/or complementary effects: the enhanced DNA structural recognition and DNA binding as well as
in vitro anticancer activities. This review overviews some representative polynuclear ruthenium
complexes acting as DNA structural probes, DNA binders and in vitro anticancer agents, which were
developed during last decades. These complexes are reviewed according to two main categories of
homo-polynuclear and hetero-polynuclear complexes, each of which is further clarified into the metal
centers linked by rigid and flexible bridging ligands. The perspective, challenges and future efforts
for investigations into these exciting complexes are pointed out or suggested.
