Title:Real-time Monitoring of Nanoparticle-based Therapeutics: A Review
Volume: 19
Issue: 2
Author(s): Qingqing Han, Meng Niu, Qirun Wu and Hongshan Zhong*
Affiliation:
- Department of Radiology, China Medical University, Shenyang,China
Keywords:
Nanoparticle drugs, metal nanoparticles, nanoliposomes, solid lipid nanoparticles, surface-enhanced Raman scattering, PTT,
MRI.
Abstract: Background: With the development of nanomaterials, nanoparticle-based therapeutics have found increasing
application in various fields, including clinical and basic medicine. Real-time monitoring of nanoparticle-based
therapeutics is considered critical to both pharmacology and pharmacokinetics.
Methods: In this review, we discuss the different methods of real-time monitoring of nanoparticle-based therapeutics
comprising different types of nanoparticle carriers, such as metal nanoparticles, inorganic nonmetallic nanoparticles,
biodegradable polymer nanoparticles, and biological nanoparticles.
Results: In the light of examples and analyses, we conclude that the methods of analysis of the four types of nanoparticle
carriers are commonly used methods and mostly not necessary. Under most circumstances, real-time monitoring
differs according to nanoparticle type, drugs, diseases, and surroundings.
Conclusion: With technology development and advanced researches, there have been increasing measures to track
the real-time changes in nanoparticles, and this has led to great progress in pharmacology and therapeutics. However,
future studies are warranted to determine the accuracy, applicability, and practicability of different technologies.
