Title:Proprotein Convertase Subtilisin/kexin type 9 Inhibition in Cardiovascular Prevention
Volume: 24
Issue: 4
Author(s): Ali Ali, Pierluigi Costanzo and Angela Hoye*
Affiliation:
- Department of Academic Cardiology, University of Hull, Kingston upon Hull,United Kingdom
Keywords:
Cholesterol, LDL, PCSK9 inhibitors, statins, serum LDL-C, hypercholesterolemia.
Abstract: Elevated levels of Low Density Lipoprotein cholesterol (LDL-C) are directly associated with increased
risk for atherosclerotic cardiovascular and cerebrovascular events. Statins have been used to control serum LDLC
and this has translated into reduction in cardiovascular and cerebrovascular events. However, despite high dose
statin therapy, LDL-C control may remain inadequate in some patients, particularly those with familial hypercholesterolemia.
A new therapeutic approach has emerged in recent years with proprotein convertase subtilisin/kexin
type 9 (PCSK9) inhibitors.
In this review, we describe the development and the use of this new class of drugs.
