Title:Drug-Coated Balloons: Technologies and Clinical Applications
Volume: 24
Issue: 4
Author(s): Huiying Ang, Jinjie Lin, Ying Ying Huang, Tze Tec Chong, Salvatore Cassese, Michael Joner and Nicolas Foin*
Affiliation:
- National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609,Singapore
Keywords:
Drug-eluting balloon, drug-coated balloon, peripheral interventions, coronary artery disease, paclitaxel, restenosis.
Abstract: The progress and development of drug-coated balloons (DCBs) represents an emerging alternative
treatment in peripheral and coronary artery diseases, particularly when a non-stent approach is necessary. Several
studies and meta-analyses have evaluated the clinical outcomes of DCBs in different lesions and this review aims
to compile the progress and updated clinical data of DCB strategy in both peripheral artery diseases (PAD) and
coronary artery diseases (CAD). The review highlights that clinical data has encouraged the use of DCB for applications
in PAD and in the treatment of coronary in-stent restenosis (ISR). The employment of DCB in side
branch treatment of bifurcation lesions has been reported to be feasible and safe, with good angiographic and
clinical outcome. The use of DCB for arteriovenous fistula and grafts stenoses is a promising strategy, but more
clinical data is required to draw reliable conclusions. The limitations and impact of the current generation of
DCBs will be discussed and the clinical development of newer generation of the device is also covered in this
review.
