Title:Nanofibers: An Effective Tool for Controlled and Sustained Drug Delivery
Volume: 15
Issue: 2
Author(s): Amandeep Singh, Goutam Rath, Ranjit Singh and Amit K Goyal*
Affiliation:
- Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab,India
Keywords:
Electrospun fibers, uniaxial, scaffolds, polymer, coaxial, sustained release, drug delivery.
Abstract: Background: Electrospun nonwoven nanofibers are emerging as a novel carrier for verity of
drugs meant for treatment of infections, disorders and tissue engineering scaffolds. These systems may
used widely in controlled release of drug that are beneficial for the health management. Nonwoven
structures may provide great surface area, absorbable, simplistic processing and economical. For water
loving small molecule drugs, their high water solubility and poor partition and compatibility issues with
polymers make it long term release yet more challenging.
Methods: Several strategies have been explored to control the release of hydrophilic drugs with high
drug payload in electrospun fibers. Various techniques like blending, co-axial electrospinning can be
used to improve drug payload.
Results: Studies have suggested that electrospinning methods are important attributes of developed
nanofibers. Further, types of polymers are also important contributory factor on drug load and release.
This review gives an overview of nanofibers used for controlled and sustained release for drugs.
Conclusions: This articles enlightened that physicochemical and biological properties of nanofibers
may be regulated by changing processing and formulation parameters.
