Title:Management of Hemophilic Arthropathy of the Ankle
Volume: 17
Issue: 2
Author(s): E. Carlos Rodriguez-Merchan*
Affiliation:
- Department of Orthopaedic Surgery, La Paz University Hospital, Madrid,Spain
Keywords:
Hemophilia, ankle, hemophilic arthropathy, treatment, hemorrhages, radiosynovectomy.
Abstract: Background: Hemophilic arthropathy (HA) of the ankle is prevalent in people with hemophilia
(PWH). It is frequently severe and incapacitating, due to recurrent bleeding into the ankle
articulation during infancy. Around 50% of hemophilic patients suffer from ankle pain and radiological
signs of HA.
Objective: To review current treatment of HA of the ankle in PWH.
Method: A literature review of hemophilic ankle arthropathy in PWH was performed utilizing
MEDLINE (PubMed) and the Cochrane Library.
Results: Primary hematologic prophylaxis could keep away from the development of ankle HA if
the level of the patient's deficient factor is prevented from dropping below 1% of normal. Recurrent
articular bleeding can be prevented by the intravenous infusion of clotting factor concentrates (prophylaxis).
Major articular bleeds and chronic hemophilic synovitis should be managed fiercely to
prevent ankle HA. In the circumstance of advancing articular involvement, some noninvasive and
invasive procedures can procure symptomatic mitigation and ameliorate the patient’s function and
quality of life.
Conclusion: The ideal treatment for the hemophilic ankle when hematologic prophylaxis fails
includes physical medicine and rehabilitation, orthoses, radiosynovectomy, arthroscopic ankle
debridement (in the initial stages of cartilage degeneration), and ankle distraction, ankle fusion or
total ankle replacement (in advanced stages of cartilage degeneration).
