Title:Chemistry and Applications of 4-Hydroxyquinolin-2-one and Quinoline-2,4-dionebased Compounds
Volume: 21
Issue: 19
Author(s): Karel Proisl, Stanislav Kafka*Janez Kosmrlj*
Affiliation:
- Faculty of Technology, Tomas Bata University, Vavreckova 275, CZ-760 05 Zlin,Czech Republic
- Faculty of Chemistry and Chemical Technology, University of Ljubljana, Vecna pot 113, SI-1000 Ljubljana,Slovenia
Keywords:
4-hydroxyquinolin-2-one, quinoline-2, 4-dione, organic synthesis, biological activity, applications, anticonvulsive effects.
Abstract: Background: 4-Hydroxyquinolin-2-ones and quinoline-2,4-diones, a subset of the quinolone scaffold,
have attracted attention due to their biological properties. These structures are present in many classes of natural
products and pharmaceutical agents and show promise in antiviral and antibacterial treatment. They possess anticonvulsive
effects, selective affinity to cannabinoid receptors, and other interesting biological activity. Some of
these compounds have the potential for protection and properties modification of natural as well as synthetic materials
as antioxidants, antidegradants, antifungal agents, UV absorbers, optical brighteners, luminophores, etc.
Objective: The importance of these compounds stimulated the development of innovative conventional and modern
catalytic methods for their preparation. The present review highlights recent progress in the above subjects
