Title:1h Post-load Blood Glucose in the Identification of Proatherogenic Cardiometabolic Profile in Obesity
Volume: 17
Issue: 3
Author(s): Djordje S. Popovic*, Dragana Tomic-Naglic, Milena Mitrovic, Zeljko Zivanovic, Bojan Vukovic and Edita Stokic
Affiliation:
- Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Center of Vojvodina, Medical Faculty, University of Novi Sad, Hajduk Veljkova 1, 21000 Novi Sad,Serbia
Keywords:
1h post-load blood glucose, 2h post-load blood glucose, cardiovascular diseases, fasting blood glucose, glucose
metabolism, metabolic syndrome, obesity, prediabetes, screening, type 2 diabetes.
Abstract: Background and Aim: Current data show that 1h oral glucose tolerance test (OGTT)
blood glucose (1h-BG) might identify persons at increased risk of developing type 2 diabetes and
cardiovascular diseases more precisely than fasting blood glucose (FBG) and 2h OGTT blood glucose
(2h-BG). The aim of study was to determine whether is justified to use 1h-BG over traditional
blood glucose measurements, in cardiometabolic profiling of obese individuals.
Method: Cross-sectional study enrolled 60 obese individuals without previous history of diabetes
and other cardiometabolic disorders. Anthropometrical, ultrasound and laboratory examinations
were conducted.
Results: All three parameters significantly directly correlated with age, body mass index, waist circumference,
erythrocyte sedimentation rate, C-reactive protein, triglycerides and glycated hemoglobin.
FBG and 1h-BG significantly directly correlated with alanine transaminase, gammaglutamyltransferase
and total cholesterol. FBG significantly directly correlated with fibrinogen and
aspartate transaminase, 1h-BG with systolic blood pressure and 2h-BG with diastolic blood pressure.
None of parameters significantly correlated with gender, total white blood cell count, uric acid,
25-hydroxyvitamin D, high density lipoprotein cholesterol, low density lipoprotein cholesterol, serum
adiponectin and albuminuria. Differences in correlation coefficients were not statistically significant.
Individuals with 1h-BG >8.6 mmol/l had much more proatherogenic cardiometabolic profile,
as well as higher incidence of dysglycemia, metabolic syndrome (MetS) and non-alcoholic fatty
liver disease (NAFLD) than ones with 1h-BG <8.6 mmol/l, but all differences were driven by the
average value of glycemia. There were no statistically significant differences in ability of predicting
MetS, NAFLD and pathologically increased carotid artery intima media thickness among analyzed
glucose metabolism parameters.
Conclusion: 1h-BG is not superior to FBG and 2h-BG in the identification of proatherogenic cardiometabolic
profile in obesity.
