Title:Vitamin D Metabolism and Potential Effects of Vitamin D Receptor Modulation in Chronic Kidney Disease
Volume: 18
Issue: 7
Author(s): Antonio Bellasi*, Andrea Galassi, Michela Mangano, Luca Di Lullo and Mario Cozzolino
Affiliation:
- Renal and Dialysis Division Ospedale Sant’Anna-Como, ASST-Lariana, Via Ravona, 20 – 22020 Como,Italy
Keywords:
CKD-MBD, vitamin D, paracalcitol, Vitamin D receptor, vitamin D deficiency.
Abstract: Background: Vitamin D deficiency is one determinant of secondary hyperparathyroidism in the course of
Chronic Kidney Disease (CKD). However, numerous studies support the notion that vitamin D may exert pleiotropic
effects aside of mineral metabolism control. Indeed, vitamin D receptor has been identified in a great variety of
tissues and its activation contributes to the parathyroid, intestine, cardiovascular and immune system regulation.
Conclusion: We herein review vitamin D metabolism and effects with a specific emphasis on the potential impact of
vitamin D receptor modulation aside from parathyroid hormone control.
