Title:Potential Molecular Targets of Ampelopsin in Prevention and Treatment of Cancers
Volume: 17
Issue: 12
Author(s): Xianjuan Kou, Jingjing Fan and Ning Chen*
Affiliation:
- Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079,China
Keywords:
Natural product, ampelopsin, chemotherapy, signal pathway, molecular mechanism, cancer.
Abstract: Cancers have increased threat to human health due to the limited treatment efficacy of chemotherapy
and radiotherapy with a series of toxicity and side effects; therefore, the development and utilization of natural
products with potential preventive and therapeutic efficacy, and less toxicity and side effects will be beneficial
to promote the health of cancer patients. In this article, the activity of ampelopsin as a natural flavonoid and
its underlying molecular mechanisms for the prevention and treatments of hepatic carcinoma, breast cancer,
prostate cancer and melanoma through inhibiting cell proliferation, accelerating apoptosis, inducing reactive
oxygen species (ROS) generation and endoplasmic reticulum (ER) stress, suppressing angiogenesis, invasion
and metastasis, and synergizing the efficacy of other anti-cancer drugs have been summarized. This study will
provide a reference for the development and utilization of other natural products.
