Title:Berberine Derivatives with Different Pharmacological Activities via Structural Modifications
Volume: 18
Issue: 17
Author(s): Daipeng Xiao, Zhenbao Liu, Shanshan Zhang, Mi Zhou, Fen He, Ming Zou, Junying Peng, Xiong Xie, Yanfei Liu*Dongming Peng*
Affiliation:
- Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Central South University, Changsha 410083,China
- Department of Medicinal Chemistry, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208,China
Keywords:
Berberine, bioavailability, chemical transformation, mechanisms, pharmacological activities, structural modification.
Abstract: Berberine, a quaternary ammonium protoberberine alkaloid with an isoquinoline scaffold
isolated from medicinal herbs, exhibits a wide spectrum of pharmacological activities. Berberine has
been used in traditional Chinese medicine and Ayurvedic medicine. However, it has poor bioavailability,
which seriously limits its application and development. The chemical transformation of natural
products is an effective method to improve pharmacological activities. Researches have been carried
out on the modification of berberine to obtain better pharmacological properties. In this paper, the
structural modifications of berberine for different biological activities and its underlying mechanisms
are reviewed.
