Title:Trypanothione Reductase: A Target for the Development of Anti- Trypanosoma cruzi Drugs
Volume: 17
Issue: 11
Author(s): Karina Vázquez, Margot Paulino, Cristian O. Salas, Juan J. Zarate-Ramos, Brenda Vera and Gildardo Rivera*
Affiliation:
- Centro de Biotecnologia Genomica, Instituto Politecnico Nacional, Boulevard del Maestro, s/n, Esquina Elías Piña, Reynosa, 88710,Mexico
Keywords:
Chagas disease, trypanothione reductase, Trypanosoma cruzi, target, drugs, inhibitors.
Abstract: Background & Objective: Chagas disease or American trypanosomiasis is a major parasitic
disease in Latin America with restricted available treatment: nifurtimox and benznidazole. These two
drugs are ineffective in the chronic phase of the disease; therefore, there is a need for the development
of new, efficient and safe drugs for the treatment of this pathology. With this goal, one of the promising
targets is trypanothione reductase (TR), a key enzyme in the metabolism of Trypanosoma cruzi.
Conclusion: In this review, we analyse the importance of TR as a drug target, as well as the well-known
and new inhibitors reported in the last decade as potential therapeutic agents for Chagas disease.
