Title:Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin
Volume: 18
Issue: 3
Author(s): Solomon Habtemariam*Abebech Belai
Affiliation:
- Pharmacognosy Research Laboratories & Herbal Analysis Services, Chatham-Maritime, Kent ME4 4TB,United Kingdom
Keywords:
Antiinflammatory, Crohn's disease, inflammatory bowel disease, quercetin, rutin, ulcerative colitis.
Abstract: Inflammatory bowel disease (IBD), commonly represented by ulcerative colitis and Crohn's
disease, is a form of chronic inflammatory disorders of the gastrointestinal system. Its current drug
treatment includes the use of antibiotics, 5-aminosalicylates, corticosteroids, immune-modifying agents
and biologics such as anti-TNF agents and adhesion molecules blockers. These drugs have inherent
problems of efficacy as many IBD sufferers need surgical intervention at some stage, high cost especially
for the protein-based drugs, loss of efficacy and unwanted side effects. The discovery of novel drugs
including those from natural sources that overcome the above mentioned drawbacks of the current
therapy is therefore of great interest. While the flavonoid quercetin with proven antiinflammatory effect
failed to show activity in vivo, its glycoside rutin has recently proven to possess a significant IBD
therapeutic potential in experimental animals. In this communication, the pharmacological and pharmacokinetic
profiles of rutin along with its ability to serve as a prodrug that deliver the bioactive quercetin
close to the IBD site are discussed. Potential mechanisms of action far beyond antioxidant effects
such as suppression of proinflammatory mediators' release and expression of inflammatory proteins
(e.g. adhesion molecules, cyclooxygenase, nitric oxide synthase, etc.) are also scrutinized.
