Title:Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Sulfonamide-benzothiazole Derivatives of Benzylidene-2,4- thiazolidnedione
Volume: 17
Issue: 8
Author(s): Abbas Ahmadi*, Mohsen Khalili, Lida Sohrabi, Nazanin Delzendeh, Babak Nahri-Niknafs and Fariba Ansari
Affiliation:
- Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, No 99, Yakhchal, Gholhak, Shariati, Tehran,Iran
Keywords:
Hypoglycemic and hypolipidemic activities, STZ-induced diabetic rat model, Sulfonamide-benzothiazole
Derivatives, Thiazolidinediones (TZDs).
Abstract: Background: Thiazolidinediones (TZDs) and sulfonamides are important and highly
consumption class of antidiabetic drugs having insulin sensitizing and stimulating properties in patients
with type 2 diabetes, respectively.
Objective: In this paper, some novel benzothiazole derivatives of TZD-sulfonamides were synthesized
(I-IV) and evaluated for anti-hyperglycemic and anti-hyperlipidemic activities in the STZ-induced
diabetic rat model.
Results: Results indicated that all new conjugated compounds showed significant hypoglycemic
activities compared to control animals that were better for I and IV than others. Moreover, these new
compounds displayed high efficiency for lowering lipid profiles as compared to control and standard
(Pioglitazone) groups that was significant and higher for I than others.
Conclusion: It is concluded that these new conjugated TZD-sulfonamide-benzothiazoles (I-IV) can
indicate useful results for hypoglycemic and hypolipidemic activities compared to control and standard
groups, respectively with different mechanism that is closer to TZDs' analogs.
