Title:Effect of Administration of Nandrolone Decanoate upon Aldosterone Concentration and Serum Na+/K+ Levels in Albino Mice
Volume: 14
Issue: 3
Author(s): Parmita Chowdhury and Rita Mahanta
Affiliation:
Keywords:
Albino mice, aldosterone, anabolic androgenic steroid, drug abuse, nandrolone decanoate, potassium, sodium.
Abstract: Background: This article is a study of adverse effects associated with the abuse of recreational
drugs such as anabolic androgenic steroids. Nandrolone decanoate is one such drug often abused
by athletes and bodybuilders seeking enhanced physical strength or appearance. The use of such steroids
has increased dramatically over the years.
Objective: The present study was conducted to investigate the impact of nandrolone decanoate when
consumed at an abused dose, upon serum aldosterone concentration in albino mice. Sodium and potassium
ion concentrations were also monitored with the same experimental dosage.
Method: 0.1ml of 25 mg Nandrolone decanoate was administered to the animals twice a week for a period
of 90 days. Blood samples for obtaining the serum from both normal and treated group of animals
were collected at an interval of 15 days upto the 90th day.
Result: The present investigation revealed a significant increase (p<0.01) in the serum aldosterone and
sodium ion concentrations in the treated group of animals compared to that in the normal group. Potassium
ion concentration in the treated group did not exhibit a significant alteration when compared with
the untreated animals.
Conclusion: From the above observation, nandrolone decanoate abuse could be suggested as one of the
causes of aldosterone and electrolyte imbalance in the body that could possibly be a serious risk factor
for cardiovascular related disorders.
