Title:Kinase Inhibitor Indole Derivatives as Anticancer Agents: A Patent Review
Volume: 12
Issue: 1
Author(s): Anuj K. Rathi, Riyaz Syed, Vijay Singh, Han-Seung Shin and Rahul V. Patel
Affiliation:
Keywords:
Anticancer, drug designing, indole, kinase inhibitors, patents.
Abstract: Cancer accounts for a number of deaths each year. Consequently, prevention of this deadly
disease is more challenging and hence the invention of new anticancer agents is of utmost importance.
The current review elaborates the importance of indole designs as patented in the form of anticancer druglike
molecules targeting different cites of biological arena. Specific attention was given to kinases such as
platelet-derived growth factor receptor, vascular endothelial growth factor receptor and fibroblast growth
factor receptor, Bruton's tyrosine kinase, anaplastic lymphoma kinase, Janus kinase, cyclin-dependent
kinase aurora kinases A, B and C, checkpoint kinases, protein kinase R, Pim kinases, phosphoinositide 3-
kinase, altered proteins kinases, polo-like kinase and many more. Moreover, the article summarizes the
mode of action through the particular functions of kinases and the inhibitory potential of indole derivatives
toward specific kinase. Certain patents gathered in the existing review article suggest that indole
core can be a versatile foundation to discover drug-like kinase inhibitor molecules and modification of
substituents existing on the indole moiety may have important impact on the pharmacokinetic and pharmacodynamics
aspects of the resultant scaffolds. The information presented here would gather a great
deal of interest to identify the new molecular designs bearing indole nucleus presenting novel anticancer
drugs with a wide variety of biological targets involved in cancer pathology focusing on the inhibition of
tyrosine kinases, serine/threonine-specific protein kinases, cyclin-dependent kinases, lipid kinases and
altered protein kinases.
