Title:Stem Cell Therapies for Intracerebral Hemorrhages
Volume: 14
Issue: 6
Author(s): Norihito Shimamura*, Naoya Mtsuda, Kosuke Ktayama, Kiyohide Kakuta, Takeshi Katagai, Masato Naraoka and Hiroki Ohkuma
Affiliation:
- Department of Neurosurgery, Hirosaki University Graduate School of Medicine, 5-Zaihuchou, Hirosaki Aomori Pref. 036-8562,Japan
Keywords:
Functional recovery, intracerebral hemorrhage, migration, muse cell, proliferation, stem cell.
Abstract: Background: An insult due to intracerebral hemorrhage (ICH) is critical to patients. So,
breakthroughs in ICH treatment are very important.
Objective: Advances in the stem cell treatment of stroke have been remarkable. And stem cell experimentation
on ischemic stroke, however, preceded such work on ICH and did not emphasized ICH therapy.
Method: We review recent stem cell treatments for ICH, an experimental model of ICH, the medical
care of ICH, and several stem cell therapies for ICH along with future prospects.
Results: Stem cell therapy for ICH is effective in rodent or animal models. For humans, only a small
number of clinical trials have been done, and significant functional recovery was recorded.
Conclusion: We need to reveal the mechanism of stem cell therapy and develop a reliable, definitive
treatment strategy for treatment of ICH. In the future, several types of stem cells will be available for
the treatment of ICH.
