Title:Anti-inflammatory Action of Green Tea
Volume: 15
Issue: 2
Author(s): Tomokazu Ohishi, Shingo Goto, Pervin Monira, Mamoru Isemura and Yoriyuki Nakamura
Affiliation:
Keywords:
Catechin, cyclooxygenases, green tea, IL-1β matrix metalloproteinase, NF-κB, reactive oxygen
species, TNF-α.
Abstract: Background: Green tea has been shown to have beneficial effects against a variety
of diseases such as cancer, obesity, diabetes, cardiovascular disease, and neurodegenerative
diseases. Through cellular, animal, and human experiments, green tea and its major component,
epigallocatechin-3-gallate (EGCG) have been demonstrated to have anti-inflammatory
effects. Our previous findings have indicated that green tea and EGCG suppress the gene
and/or protein expression of inflammatory cytokines and inflammation-related enzymes.
Methods: Using bibliographic databases, particularly PubMed (provided by the
http://www.ncbi.nlm.nih.gov/pubmed, US National Library of Medicine, National Institutes
of Health, United States), we examined the potential usefulness of green tea/EGCG for the
prevention and treatment of inflammatory diseases in human clinical and epidemiological
studies. We also reviewed results from cellular and animal experiments and proposed action
mechanisms.
Results: Most of the results from the human studies indicated the beneficial effects of green
tea and tea catechins against inflammatory diseases. The cellular and animal studies also provided
evidence for the favorable effects of green tea/EGCG. These results are compatible
with our previous findings and can be largely explained by a mechanism wherein green
tea/EGCG acts as an antioxidant to scavenge reactive oxygen species, leading to attenuation
of nuclear factor-κB activity.
Conclusion: Since green tea and EGCG have multiple targets and act in a pleiotropic manner,
we may consider their usage to improve the quality of life in patients with inflammatory disease.
Green tea and EGCG have beneficial health effects and no severe adverse effects; however,
care should be taken to avoid overdosage, which may induce deleterious effects including
hepatic injury.
