Title:New Adamantyl Chalcones: Synthesis, Antimicrobial and Anticancer Activities
Volume: 17
Issue: 4
Author(s): Aouatef Tabbi, Dahmane Tebbani, Angelamaria Caporale, Carmela Saturnino, S. F. Nabavi, Palma Giuseppe, Claudio Arra, Zerrin Canturk, Gulhan Turan-Zitouni, Hocine Merazig, Eduardo Sobarzo-Sanchez and Luca Rastrelli
Affiliation:
Keywords:
Adamantyl chalcones, Antimicrobial activity, Antifungal activity, Anticancer activity, MiaPaca2, NMR.
Abstract: Background: A new variety of adamantyl chalcones (2, 3a-o) were efficiently prepared by
Claisen-Schmidt reaction of 4-adamantyl acetophenone 2 with a serie of aromatic aldehydes in good
yields. Their structures were confirmed by spectroscopic data, and the relative configuration of 3d was
confirmed by X-ray crystallography. All synthesized chalcones were tested against a panel of Grampositive
and Gram-negative bacteria and pathogenic fungus and displayed strong antibacterial activity
against Enterococcus faecali 29212, Pseudomonas aeruginosa ATCC27853, Escherichia coli and interesting
antifungal activity against Candida glabrata ATCC 90030.
Result: The effect of these compounds was also tested in vitro as antitumor on Miapaca2 cells. Compounds
also showed anticancer activity against human pancreas cancer cell MiaPaca2.
