Title:Ursolic Acid and Oleanolic Acid: Pentacyclic Terpenoids with Promising Anti-Inflammatory Activities
Volume: 10
Issue: 1
Author(s): Dharambir Kashyap, Ajay Sharma, Hardeep S. Tuli, Sandeep Punia and Anil K. Sharma
Affiliation:
Keywords:
Chemistry, inflammation, mechanisms, oleanolic acid, patent, ursolic acid.
Abstract: Background: Plant derived products are not only served as dietary components but also
used to treat and prevent the inflammatory associated diseases like cancer. Among the natural products
pentacyclic terpenoids including ursolic acid and oleanolic acid are considered as the promising anti-inflammatory therapeutic
agents.
Objectives: The current review extensively discusses the anti-inflammatory therapeutic potential of these pentacyclic
moieties along with their proposed mechanisms of action. Furthermore, the relevant patents have also been listed to present
the health benefits of these promising therapeutic agents to pin down the inflammatory diseases.
Expert opinion: Pentacyclic terpenoids are known to negatively down-regulate a variety of extracellular and intracellular
molecular targets associated with disease progression. The major anti-inflammatory effects of these molecules have been
found to be mediated via inactivation of NF, STAT3/6, Akt/mTOR pathways. A number of patents on UA & OA based
moieties have been reported between 2010 and 2016. Still there have been only a few compounds which meet the need of
sufficient hydro solubility and bioavailability along with higher anti-inflammatory activities. Thus, it is essential to develop
novel derivatives of terpenpoids which may not only overcome the solubility issues but also may improve their
therapeutic effects. In addition, scientific community may utilize nanotechnology based drug delivery systems so as to increase
the bio-availability, selectivity and dosages related problems.
