Title:Synthetic and Medicinal Prospective of Structurally Modified Curcumins
Volume: 17
Issue: 2
Author(s): Bhupinder Kumar, Virender Singh, Ravi Shankar, Kapil Kumar and Ravindra K. Rawal
Affiliation:
Keywords:
Curcumine, Heterocycle, Cancer, Alzheimer, Tubercular, Parkinson's.
Abstract: Curcumin, a natural yellow phenolic compound, is present in various types of herbs, particularly
in Turmeric, Curcuma longa Linn. (Zingiberaceae family) rhizomes. Curcumin is a polyphenolic
natural compound with diverse and attractive biological activities. In the last decade curcumine
and its various synthetic analogues have been prepared and evaluated for various pharmacological
activities that prove it as a lead molecule against several biological targets. It is a natural antioxidant
and exhibited many pharmacological activities such as anti-inflammatory, anti-microbial, anticancer,
anti-Alzheimer in both preclinical and clinical studies. Moreover, Curcumin and its analogues
have anti-tubercular, cardioprotective, anti-diabetic, hepatoprotective, neuroprotective, nephroprotective,
antirheumatic and anti-viral activities. The substitutions of 1,6-heptadiene linkage moiety via
carbonyl group sustituion and addition of heterocyclic linker; isoxazole, 1H-pyrazole, cyclopentanone,
piperidin-4-one, N-methylpiperidin-4-one enhance biological activities. The structure activity
relationship of various curcumin analogues is studied for medicinal purposes and it reveals that
monocarbonyl linkage analogues have anticancer properties. The current review gives an insight of
the history, chemistry, analogues and most interesting in vitro and in vivo studies on the biological effects
of Curcumin and its analogues.
