Title:The Connections Among Autophagy, Inflammasome and Mitochondria
Volume: 18
Issue: 9
Author(s): Isabel de Lavera, Ana Delgado Pavon, Marina Villanueva Paz, Manuel Oropesa-Avila, Mario de la Mata, Elizabet Alcocer-Gomez, Juan Garrido-Maraver, David Cotan, Monica Alvarez-Cordoba and Jose A. Sanchez-Alcazar*
Affiliation:
- Centro Andaluz de Biología del Desarrollo [CABD]. Universidad Pablo de Olavide-Consejo Superior de Investigaciones Científicas. Carretera de Utrera Km 1, Sevilla 41013,Spain
Keywords:
Autophagy, cytokines, inflammasome, mitochondria, NLRP3, ROS.
Abstract: Background: The molecular crosstalk between inflammation and autophagy is an emerging
field of research that is essential for the understanding of multicellular organism homeostasis and
how these processes influence a variety of pathological conditions.
Objective: In this review, we briefly describe the relationship between autophagy and inflammasome
activation. The central role that mitochondria play in both cellular processes is also discussed.
Conclusion: Inflammasome and autophagy often modulate each other by common inhibitory mechanisms
that are controlled by different input pathways. Thus, inflammasome components coordinate
autophagy and autophagy regulates inflammasome activation, making the balance between both processes
a fundamental player in cellular homeostasis.
