Title:Lack of Association Between SLC24A4 Polymorphism and Late-onset Alzheimer's Disease in Han Chinese
Volume: 13
Issue: 3
Author(s): Huan Lu, Xi-Chen Zhu, Hui-Fu Wang, Lei Cao, Meng-Shan Tan, Chen-Chen Tan, Teng Jiang, Jin-Tai Yu and Lan Tan
Affiliation:
Keywords:
Alzheimer’s disease, polymorphism, SLC24A4, association study, susceptibility, rs10498633.
Abstract: Recently, a single nucleotide polymorphism rs10498633 on solute carrier family 24 member 4 (SLC24A4) was
revealed to be closely related to the risk of late-onset Alzheimer's disease (LOAD) in a large genome-wide association
study containing 74046 individuals in Caucasians. However, no study was performed to validate this relation in other ethnic
populations, including Han Chinese. Therefore, we recruited 992 LOAD patients and 1358 age- and sex- matched
healthy controls to validate the association between rs10498633 and LOAD susceptibility in Han Chinese. In our total
sample, no significant difference was observed between the minor (T) allele of rs10498633 and LOAD risk under a dominant
genetic model (OR=0.903, 95% CI: 0.738-1.104, P=0.320). In addition, no significant relation was noted between
rs10498633 and LOAD risk in neither apolipoprotein E (APOE) ε4 carriers nor non-carriers after adjusting for age and
gender. Therefore, our findings indicate that rs10498633 may not play a major role in LOAD susceptibility in Han Chinese.
