Title:Heterocyclic Naphthalimides as New Skeleton Structure of Compounds with Increasingly Expanding Relational Medicinal Applications
Volume: 16
Issue: 28
Author(s): Huo-Hui Gong, Dinesh Addla, Jing-Song Lv and Cheng-He Zhou
Affiliation:
Keywords:
Antibacterial, Anticancer, Antifungal, Antiviral, Artificial ion receptor, Diagnostic agent, Naphthalimide, Pathologic probe.
Abstract: Naphthalimide compounds are an important type of nitrogen-containing aromatic heterocycles
with cyclic double imides and the naphthalene framework. This π-deficient large conjugated planar
structure enables naphthalimide derivatives to readily interact with various biological cations, anions,
small molecules and macromolecules such as DNAs, enzymes and recetors in living organism via noncovalent
bonds, therefore exhibiting extensive potentiality in relatively medicinal applications. Currently,
some naphthalimides as anticancer agents have entered into clinical trials and other naphthalimide-based medicinal developments as potential drugs for treatment of various diseases are actively
and unprecedentedly expanding. Naphthalimide-derived artificial ion receptors, fluorescent probes and
cell imaging agents are being overwhelmingly investigated and have a diversity of potential applications
in real-time detecting ions and biomolecules, understanding biological processes and determining pharmacological
and pharmacokinetic properties. All the above mentions have strongly implied that naphthalimide-based derivatives as new skeleton structure of compounds possess increasingly expanding relational
medicinal applications, and the related research is becoming a quite attractive active topic and
newly rising highlight. Combining with our research and referring other works from literature, this work
systematically reviews the current research and development of heterocyclic naphthalimides as anticancer,
antibacterial, antifungal, antiviral, anti-inflammatory, antidepressant agents as well as artificial
cation and anion receptors, diagnostic agents and pathologic probes, and cell imaging agents for biologically
important species. Some rational design strategies, structure-activity relationships and action
mechanisms are discussed. The perspectives of the future development of naphthalimide-based medicinal
chemistry are also presented.
