Title:Pyridines and Imidazopyridines with Medicinal Significance
Volume: 16
Issue: 28
Author(s): Tara L.S. Kishbaugh
Affiliation:
Keywords:
Anti-microbial, Anticancer, Anticonvulsant, Antihypertensive, Imidazopyridines, Medicinal Significance, NSAID,
Pyridines.
Abstract: Pyridine and pyridine-fused ring systems are ubiquitous in medicinal research and demonstrate
such diverse pharmacological benefits as anticonvulsant therapies, treatment for fungal and
bacterial infections as well as chemotherapy agents. For example, imidazo[1,2-a]pyridines have exhibited
a broad range of activity as antiviral, antibacterial, analgesic, antipyretic, and antiinflammatory
agents. Indeed many advances in the development of novel synthetic approaches to the
pyridines and their fused counterparts are designed around the relevance of these systems to pharmacological
research. Moreover, pyridine-based natural products with interesting biological activity continue
to be discovered each year. This article highlights recent (2004-2014) discoveries related to the
medicinal and pharmacological significance of pyridines, imidazo[1,2-a]pyridines, quinolones and a
few other pyridine-fused compounds and is organized around their type of biological activity.
