Title:Exploring Pyrimidine Pharmacophore as Thymidine Monophosphate Kinase Inhibitors for Antitubercular Activity: A Review
Volume: 16
Issue: 28
Author(s): Trupti Sameer Chitre, Kalyani Dhirendra Asgaonkar, Shital Manoj Patil, Muthu Kumaradoss Kathiravan and Subhash Balkrishna Padhye
Affiliation:
Keywords:
Tuberculosis, Thymidine Monophoshate Kinase (TMPKmt) inhibitors, Nucleotide, Nucleoside, Pyrimidine.
Abstract: Tuberculosis (TB) has been declared as a health emergency due to emergence of resistant
strains of M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains
and totally drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore,
the current situation necessitates developing new antitubercular agents acting on novel targets
for effectively controlling TB. Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such
target, which is being explored. This review focuses on Structure Activity Relationship studies
(SARs) and computational studies of various nucleotide and nucleoside derivatives of pyrimidine
analogs reported as TMPKmt inhibitors.
