Title:Recent Research Progress in Natural Bioactive Constituents against Lipid Metabolic Diseases
Volume: 16
Issue: 23
Author(s): Lirong Nie, Hang Song, Ai He and Shun Yao
Affiliation:
Keywords:
Natural bioactive constituents, Lipid metabolism, Regulating blood lipid, Lead compounds, Activity screening,
structure-activity relationship.
Abstract: Lipid metabolic disorder refers to the dyslipidemia in the plasma. Abnormal working or
lipid metabolism process leads to supernormal increase of one or multi kinds of lipids in plasma. It is a
significant risk factor for many diseases and has become a serious danger to the mankind health. The
clinical drugs adjusting lipid levels have a great variety in the market, side effects and adverse reactions.
Meanwhile, many Chinese herbal medicines and natural medicines have the unnegligible role of
regulating lipid metabolism, which become the research focus of medical workers in past decades.
With advantages of fewer side effects, abundant resources and multi-target functions, terrestrial and
marine bioactive constituents are proved as one of the important sources of the lead compounds in
drug discovery and have been widely applied in the treatment and prevention of lipid metabolic diseases. In this paper, the
recent advancements and current status of natural medicinal ingredients mainly based on lipid-lowering activities were reviewed
in detail. Moreover, their bioactivity screening and important mechanisms in hyperlipemia progression were
summarized and compared. It was also selectively introduced about related structural modification and new drug development
on the basis of promising lead compounds. Finally, the current problems and possible prospects of natural constituents
against lipid metabolism disorder in the future were discussed.
