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Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma

Author(s): Amy Lee Bredlau, Suraj Dixit, Chao Chen and Ann-Marie Broome

Volume 15, Issue 1, 2017

Page: [104 - 115] Pages: 12

DOI: 10.2174/1570159X14666160223121002

Price: $65

Abstract

Diffuse intrinsic pontine gliomas (DIPGs) are invariably fatal tumors found in the pons of elementary school aged children. These tumors are grade II-IV gliomas, with a median survival of less than 1 year from diagnosis when treated with standard of care (SOC) therapy. Nanotechnology may offer therapeutic options for the treatment of DIPGs. Multiple nanoparticle formulations are currently being investigated for the treatment of DIPGs. Nanoparticles based upon stable elements, polymer nanoparticles, and organic nanoparticles are under development for the treatment of brain tumors, including DIPGs. Targeting of nanoparticles is now possible as delivery techniques that address the difficulty in crossing the blood brain barrier (BBB) are developed. Theranostic nanoparticles, a combination of therapeutics and diagnostic nanoparticles, improve imaging of the cancerous tissue while delivering therapy to the local region. However, additional time and attention should be directed to developing a nanoparticle delivery system for treatment of the uniformly fatal pediatric disease of DIPG.

Keywords: Brainstem glioma, DIPG, drug delivery, liposome, micelle, nanoparticle, pons, theranostics.

Graphical Abstract

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