Title:Treatment for Cancer Patients with Oral Mucositis: Assessment Based on the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer in International Society of Oral Oncology (MASCC/ISOO) in 2013 and Proposal of Possible Novel Treatment with a Japanese Herbal Medicine
Volume: 22
Issue: 15
Author(s): Kanako Miyano, Takao Ueno, Wakako Yatsuoka and Yasuhito Uezono
Affiliation:
Keywords:
Cancer patients, chemotherapy, clinical practice guideline, hangeshashinto, hematopoietic stem cell transplant, oral mucositis, the
Mucositis study group of the Multinational Association of Supportive Care in Cancer in International Society of Oral Oncology
(MASCC/ISOO), radiotherapy.
Abstract: The cancer patients who received chemotherapy, radiotherapy, hematopoietic stem cell transplant and
terminal care often have a wide range of stomatitis, which induces severe pain and limits fundamental life behaviors
such as “eating, drinking and talking”. In addition, oral mucositis frequently leads to systemic infection
through opportunistic microorganisms, which causes extension of hospitalization. Severe oral mucositis often
causes cancer patients to partially or completely discontinue/modify cancer therapy regimen, which adversely affects
the curative effects of cancer. Therefore, the control of oral mucositis is important and indispensable for improvement
of quality of life and prognosis. In this review, we introduce recent trends of the oral mucositis management
in cancer patients, according to the following sentences; 1) pathophysiological mechanisms of oral mucositis,
2) assessment, 3) risk factors, 4) prevention and treatment, and 5) development of novel therapy for oral mucositis.
