Title:The Mechanism in Gastric Cancer Chemoprevention by Allicin
Volume: 16
Issue: 7
Author(s): Runlan Luo, Dengyang Fang, Hongdong Hang and Zeyao Tang
Affiliation:
Keywords:
Allicin, gastric cancer, cell phase arrest, apoptosis, anticancer.
Abstract: Gastric cancer remains high prevalence and fatality rates in China even though its morbidity has been
decreased drastically. Allicin, which is from an assistance food-garlic (Allium Sativum L), was found to be
effective in gastric cancer treatment. It is a defensive substance with a board biological properties: inhibition
of bacteria, fungus, virus, controlled hypertension, diabetes, and chemoprevention of several cancers, etc.
Experiments have shown that allicin can be chemopreventive to gastric cancer by inhibiting the growth of cancer
cells, arresting cell cycle at G2/M phase, endoplasmic reticulum (ER) stress, and mitochondria-mediated apoptosis,
which includes the caspase-dependent/-independent pathways and death receptor pathway. Those mechanisms
probably involve in modulating enzymatic activity, restraining DNA formation, scavenging free radicals, and
affecting cell proliferation and even tumor growth. Therefore, this review is focus on the mechanism of allicin in
gastric cancer.
