Title:Nanoplatforms for Delivery of siRNA to the Eye
Volume: 21
Issue: 31
Author(s): Manjir Sarma Kataki, Bibhuti Bhusan Kakoti, Melanie Jameson, Aum Solanki, Anjali Hirani and Yashwant Pathak
Affiliation:
Keywords:
Ocular, drug delivery, siRNA, nanoplatforms, polymers, lipid nanoparticles, proteins, dendrimers.
Abstract: Drug delivery to the eye is challenging for formulation scientists due to physiological barriers that separate
the eye from the rest of the body. A variety of ocular disorders demand the development of optimal drug delivery
systems for the administration of drugs and therapeutic agents that can overcome barriers that restrict drug
bioavailability. SiRNA inhibits the expression of target genes and has immense potential as a biological tool for the
therapeutic inhibition of disease causing genes; however, delivery of siRNA to ocular tissue is a challenge. Recent
literature suggests that nanoplatforms show great promise in enhancing ophthalmic drug delivery. A drug delivery
system involving nanoparticles and siRNA could surpass problems faced in ocular delivery with improved biodistribution
and lower toxicity. This review covers recent research in the area of nanocarrier siRNA drug delivery for
various ocular disorders.
