Title:Emerging Concepts in Diabetes: Mitochondrial Dynamics and Glucose Homeostasis
Volume: 13
Issue: 4
Author(s): Alicia G. Gómez-Valadés, Alba Gonzalez-Franquesa, Pau Gama-Perez, Marc Claret*Pablo M. Garcia-Roves*
Affiliation:
- Diabetes and Obesity Research Laboratory, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centre Esther Koplowitz, C/Rosselló 149-153, 5th floor, 08036 Barcelona,Spain
- Biophysics Unit, Department of Physiological Sciences II, IDIBELL-University of Barcelona, Campus de Bellvitge, 08907 L'Hospitalet de Llobregat, Barcelona,Spain
Keywords:
Energy metabolism, obesity, Type 2 diabetes, mitochondria, mitochondrial dynamics, fusion, fission, glucose homeostasis.
Abstract: Introduction: Mitochondria form an interconnected and dynamic web that undergoes continuous
cycles of fusion and fission events. This phenomenon, known as mitochondrial dynamics, represents
a key quality control system to maintain a healthy mitochondrial population but also a mechanism
to bioenergetically adapt to the cellular and tissue energetic demands. Consequently, mitochondria
can be viewed not only as energy supply organelles but also as energy sensors. It is therefore not surprising
that disrupted mitochondrial bioenergetics, concomitantly with alterations in mitochondrial architecture,
has been associated with several diseases including metabolic disorders.
Conclusion: Here, we review current evidences connecting mitochondrial dynamics and bioenergetic
alterations with the development of obesity and diabetes-related phenotypes, and how current strategies
to alleviate such phenotypes impact on mitochondrial network and function.
