Title:The Tree of Sirtuins and the Garden of Cardiovascular Youth
Volume: 14
Issue: 1
Author(s): Vasiliki K. Katsi, Antonios N. Pavlidis, Charalampos I. Liakos, Maria E. Marketou, Leonidas G. Raftopoulos, Nikolaos A. Alexopoulos, Thomas K. Makris, Petros Nihoyannopoulos, Dimitris Tousoulis and Ioannis E. Kallikazaros
Affiliation:
Keywords:
Sirtuins, aging, cardiovascular diseases, cancer, apoptosis, oxidative stress.
Abstract: Sirtuins (SIRTs) are a class of nicotine adenine dinucleotide (NAD+)-dependent proteins
which participate in numerous molecular pathways involved in various age-related human diseases,
such as type II diabetes, cardiovascular (CV) diseases and cancer. They have a major role in apoptosis, inflammation, oxidative
stress and metabolism regulation, traits that have a great impact on CV physiology and pathology. Their unique
profile of NAD+ energy dependency makes them an appealing target for human intervention in cellular and metabolic
processes. This review focuses on the recent advances of SIRTs research aiming to shed light on the emerging roles of
SIRTs in the pathophysiology of CV and metabolic diseases.
