Title:Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases
Volume: 21
Issue: 29
Author(s): Javier O. Morales, Sabrina Sepulveda-Rivas, Felipe Oyarzun-Ampuero, Sergio Lavandero and Marcelo J. Kogan
Affiliation:
Keywords:
Polymeric nanostructured carriers, polymeric nanoparticles, cardiovascular diseases, atherosclerosis, hypertension, endothelial
targeting.
Abstract: Applications of polymeric nanotechnologies for enabling therapies for cardiovascular diseases have
shown recent success. Both intravenous and oral administration have been investigated and achieved different degrees
of development. While circulating polymeric nanostructured carriers are subjected to a number of interactions,
smart nanoparticle design has enabled the formulation of active molecules to be delivered to specific targets
for cardiovascular effects. This review aims at outlining the multiple factors that can affect the fate of polymeric
nanostructured carriers in systemic circulation. With an understanding of these factors, the literature on the various polymeric nanostructured
carriers is reviewed. Finally, the emerging uses of nanotechnology to formulate orally administered drugs for cardiovascular diseases
are depicted.
