Title:A Novel Cobalt(II) Coordination Complex Constructed from H2Pyri and 4,4′-Bipy: Synthesis, Characterization and Bioactivity
Volume: 15
Issue: 6
Author(s): Enjun Gao, Fuchen Zhao, Mingchang Zhu and Meilin Wang
Affiliation:
Keywords:
apoptosis, Cobalt(II) complex, cytotoxicity, gel electrophoresis.
Abstract: The new complex of {[Co(4,4′-Bipy)(H2O)4]·(Pyri)·3H2O}n (4,4′-Bipy = 4,4′-bipyridyl, H2Pyri = 3,5-
Pyridinedicarboxylic acid) was synthesized and characterized by IR, element analysis and X-ray single-crystal
diffraction. The binding of the complex with extracted HeLa cells DNA was investigated by UV and fluorescence
spectrum. Gel electrophoresis assay demonstrated the ability of the complex cleaving the extracted HC-DNA. The
complex exhibited a higher cytotoxicity against tumor cells in vitro. Furthermore, the apoptotic tests indicated the
complex had an apoptotic effect on HeLa cells.
