Title:Pseudogene PTENP1 Suppresses Gastric Cancer Progression by Modulating PTEN
Volume: 16
Issue: 4
Author(s): Xiaoqiang Guo, Li Deng, Kaiyuan Deng, Hao Wang, Ting Shan, Hong Zhou, Zheng Liang, Jiazeng Xia and Chenglong Li
Affiliation:
Keywords:
Gastric cancer, long non-coding RNA, pseudogene, PTENP1, PTEN, tumor suppressor.
Abstract: PTENP1 has been demonstrated to function as a tumor suppressor in several cancer
cells. However, its expression and biological roles in gastric cancer (GC) have not yet been
investigated. In this study, we demonstrated that PTENP1 was frequently decreased in GC
tissues and cell lines, which might be partly associated with DNA hypermethylation, and lower
PTENP1 expression was associated with larger tumor size, more advanced stage, deeper
invasion depth and lymphatic metastasis. In addition, our data suggested that PTENP1 could
regulate GC cell proliferation, apoptosis, migration and invasion in vitro. Furthermore, we demonstrated that PTENP1 could modulate
the PTEN protein expression. Taken together, these results suggest that PTENP1 functions as a novel tumor suppressor in GC and its
suppressive ability may be involved in the modulation of PTEN.
