Title:Immune Thrombocytopenic Purpura: New Biological Therapy of an Old Disease
Volume: 22
Issue: 16
Author(s): Melda Comert Ozkan, Fahri Sahin and Guray Saydam
Affiliation:
Keywords:
Autoimmune disorders, biological therapy, immune thrombocytopenic purpura, rituximab.
Abstract: Immune Thrombocytopenic Purpura (ITP) is the most common autoimmune disorder that is
caused by antibody- mediated destruction of thrombocytes and impaired megakaryocyte platelet production.
ITP remains a diagnosis of exclusion. Recent pathophysiologic mechanisms and therapeutical
approaches of ITP have emerged. Although steroids and intravenous immunglobulins (IVIg) have still
been the main therapeutic strategies, a group of patients develop resistance to those eventually and
there have been some biological treatment options such as rituximab especially in the last decade. In
this review article, we have summarized the therapeutic options for patients with ITP and mainly focused
on the timing and potential effects of biological agents.
