Title:Immunostimulant Properties of Chemical Delivery Systems in Vaccine Development
Volume: 12
Issue: 4
Author(s): Sahar Hosseinzadeh and Azam Bolhassani
Affiliation:
Keywords:
Chemical carriers, delivery systems, immunomodulatory effects, vaccine development.
Abstract: One approach to improve the vaccine quality is the incorporation of immunomodulators
and/or adjuvants with modified delivery systems. The use of delivery systems especially chemical carriers
is a promising strategy in the prevention and treatment of infections, cancers, allergies and autoimmune
diseases. These systems are able to elicit an effective immune response as well as stability and
safety in vaccine development. Synthetic microparticles, liposomes, chitosan, virus like particle, polymeric
nanogel, phytosome, noisome, and micro/ nanospheres have been applied as carriers, providing
a broad variety of immunomodulatory effects in vaccines. The potency and nature of immune responses
rely on the physicochemical properties of the vaccine constructs (e.g., size and charge), the
route of injection, the biochemical characteristics and the amount of antigen. Three main steps are necessary for vaccine
efficiency such as targeting, activation and transfection/ antigen presentation. These systems can generally influence the
type and direction of immune responses. This review describes different vaccine delivery systems developed to generate
immunomodulatory effects.
