Title:New Missions for an Old Agent: Granulocyte-Colony Stimulating Factor in the Treatment of Stroke Patients
Volume: 22
Issue: 10
Author(s): Ihsan Solaroglu, Murat Digicaylioglu, G. Evren Keles and John H. Zhang
Affiliation:
Keywords:
Granulocyte-colony stimulating factor, neuroprotection, stroke, treatment.
Abstract: Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile
and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy
of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative,
and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In
this review, we summarize the role of G-CSF and the corresponding signal transduction pathways
regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
