Title:Strategies and Methods for the Synthesis of Anticancer Natural Product Neopeltolide and its Analogs
Volume: 19
Issue: 10
Author(s): Yu Bai and Mingji Dai
Affiliation:
Keywords:
Anticancer, carbonylation, macrolactone, neopeltolide, palladium, tetrahydropyran.
Abstract: Neopeltolide, isolated in 2007, with its novel structural features and potent anti-cancer cell proliferation
activity, has attracted a tremendous amount of synthetic efforts. This review briefly and chronologically summarizes
each synthesis with the main focus on the strategies and methodologies for the construction of its cistetrahydropyran-
containing macrolactone core.