Title:Recent Advance in Drug Development of Squamous Cell Carcinoma
Volume: 15
Issue: 7
Author(s): Jun Lei, Bing Fu, Hang Yin, Guanxiu Tang, Shujuan Zhu, Chunli Yan and Quanyong He
Affiliation:
Keywords:
Drug, epidermal growth factor receptor, esophageal, head and neck, lung, squamous cell carcinoma, target therapy, toll-like
receptor.
Abstract: Squamous cell carcinoma (SCC) has a high worldwide incidence that is commonly seen as head and
neck cancers, esophageal cancers, and non-small cell lung cancers. There is a poor prognosis for SCC due to
potential recurrence and its metastatic tendency so the 5-year survival rate is very low. Target therapy is a novel
and promising treatment strategy exhibiting great anti-tumor effects and survival benefits in SCC. This review
summarizes current treatment strategies from clinical and experimental studies, including the agents targeting
epidermal growth factor receptors, RNA polymerase, toll-like receptors, p38α MAPK, CXCR, and the related
combination therapy regimens. However, there are still many challenges we have to face. It is a burning need to
improve the development and availability of drug formulations.
