Title:Design, Synthesis and Antimicrobial Evaluation of Methyl Pyridyl-2,4- Dioxobutanoates and Some New Derived Ring Systems
Volume: 11
Issue: 4
Author(s): Perihan A.S. Elzahhar, Raafat Soliman, Soad A.M. El-Hawash, Hanan M.A. Ragab, Amal M. Youssef and Abeer E. Abdel Wahab
Affiliation:
Keywords:
Thiazolidin-4-one, 3, 4-dihydroquinoxalinones, 3, 4-dihydrobenzo[b][1, 4] oxazinone, 1, 2-diazepine, piperazin-2-
one, synthesis, antibacterial activity, antifungal activity.
Abstract: This work describes the synthesis of new series of compounds derived from methyl pyridyl-
2,4-dioxobutanoates that contain pyridine ring attached to substituted bioactive heterocyclic moieties
in order to investigate their preliminary in vitro antibacterial and antifungal activities. The results revealed
that most of the tested compounds exhibited significant activity against P. aeruginosa. and E.
coli. They also displayed considerable activity against S. aureus and B. subtilis. On the other hand, the
compounds displayed moderate antifungal activity.
