Title:QSAR and 3D-QSAR Models in the Field of Tubulin Inhibitors as Anticancer Agents
Volume: 14
Issue: 20
Author(s): Giovanni Marzaro and Adriana Chilin
Affiliation:
Keywords:
Colchicine, combretastatin, comfa, epothilones, QSAR, taxanes.
Abstract: Microtubules are high dynamic protein filaments fundamental for cells growth and proliferation.
Hence, tubulin inhibitors are useful anticancer compounds. Three major binding site have been identified in
tubulin, on the basis of known ligands: the vinca domain, the colchicine domain and the taxane domain. Several
compounds able to bind the colchicine and the taxane domains have been to date synthesized and evaluated.
In this review we give a description of the developed QSAR and 3D-QSAR models, giving particular attention
to those studies that give structural insight in the binding modes of compounds with the target.
