Title:Design and Optimization of Domperidone Fast Dissolving Tablet Using Central Composite Design
Volume: 12
Issue: 6
Author(s): Bhatt Shailendra, Mandge Shailendra, Jaimini Manish, Tanwar Yuveraj Singh and Trivedi Priti
Affiliation:
Keywords:
Ac-Di-Sol, central composite design, effervescent material, fast dissolving tablet.
Abstract: The main aim present work was to optimize fast dissolving tablet (FDT) formulation using
response surface approach. The variables studied were sodium bicarbonate (X1), citric acid (X2), and
superdisintegrant, Ac-Di-Sol (X3). The main aspect of present work was to develop FDT of Domperidone
which possesses fast disintegration and high mechanical strength. It was found that the response
was affected by all the three factors studied. The statistical models were successfully used to prepare
FDT of Domperidone with fast disintegration (31.08 seconds) and adequate hardness (4.1 kg/cm2). Pharmacokinetic studies
in rats showed statistically insignificant difference (p>0.05) between Domperidone fast dissolving tablet (DFDT) and
market product. This concluded that optimized FDT is bioequivalent with the marketed formulation. The values of Tmax
were found to be 0.5 h and 0.75 h for DFDT and reference product, respectively. Conditioned place aversion study was
performed on Swiss Albino mice and the study showed the better anti emetic potency of optimized FDT in nauseated condition
over market product (p<0.05). Thus, the present investigation conclusively demonstrates the potential role in terms
of rapid disintegration and high mechanical strength.
