Title:Adverse Drug Reactions Amongst Adult Patients Admitted in Lagos State University Teaching Hospital Lagos, Nigeria
Volume: 10
Issue: 2
Author(s): R. I. Aderemi-Williams, O. Awodele and C. A Boyle
Affiliation:
Keywords:
Adult, adverse drug reactions, hospitalisation, medical wards, polypharmacy.
Abstract: Background: Adverse drug reaction (ADR) is a global drug therapy problem. It has been
rated as one of the top leading causes of morbidity and mortality. In Nigeria, not much is known about
ADRs especially with the existing weak post marketing surveillance for monitoring drug use, and its
effect on the population.
Objectives: The study is aimed at determining the incidence of ADRs, presentations of ADRs, classes of drugs that
frequently cause ADRs and predictors of ADRs in adult medical in-patients in LASUTH.
Method: A retrospective study of six hundred and twenty four (624) case notes of all patients admitted to the
medical wards in LASUTH between January 1, 2009 and December 31, 2009 was carried out. Information
obtained included age, gender, and adverse drug reaction and drug details. The results obtained were analyzed
using SPSS version 16 statistical software. Level of significance was set at p ≤ 0.05.
Results: A total of 624 case notes consisting of 358 males and 266 females were assessed. The number of
patients who experienced adverse drug reactions was 67 (n = 624, 10.7%). The incidence rate of ADRs in
LASUTH from the study was 10.7 per 100 patients’ population. Most of the ADRs observed were type A
reactions (97.8%). Mostly implicated classes of drugs were antidiabetics (26.7%) and NSAIDs (29.3%).
Conclusion: The incidence rate of ADRs was 10.7%. ADRs which are predictable and preventable occur in
hospitalized patients, such may be prevented or minimized by implementing measures to target specific drugs
that are commonly suspected.
