Therapeutical Potential of CB₂ Receptors in Immune-Related Diseases

Title:Therapeutical Potential of CB₂ Receptors in Immune-Related Diseases

Volume: 6

Author(s): Natascha Leleu-Chavain, Pierre Desreumaux, Philippe Chavatte and Regis Millet

Affiliation:

Keywords: Analgesic, anticancer, antifibrogenic, anti-inflammatory, cannabinoid receptors, CB₂ agonists, immune system, immune-related diseases, liver disease, osteoporosis.

Abstract: The cannabinoid receptor CB₂ is highly expressed in immune cells suggesting an important role in numerous diseases such as inflammation, cancer, osteoporosis and liver diseases relating to modulation of the immune system. As a consequence, activation of receptor CB₂ is a promising therapeutic strategy for the treatment of a large range of diseases. Indeed, selective CB₂ agonists display beneficial anti-inflammatory, anti-cancer and antifibrogenic properties and positive effects on liver disease and osteoporosis. This article reviews the CB₂ involvement in the immune system and the promising therapeutical potential of selective CB₂ agonists in the treatment of several immune-related diseases.

Cite this article as:

Leleu-Chavain Natascha, Desreumaux Pierre, Chavatte Philippe and Millet Regis, Therapeutical Potential of CB₂ Receptors in Immune-Related Diseases, Current Molecular Pharmacology 2013; 6 (3) . https://dx.doi.org/10.2174/1874467207666140219122337