Title:Rational Considerations about Development of Live Attenuated Yersinia pestis Vaccines
Volume: 14
Issue: 10
Author(s): Wei Sun and Roy Curtiss
Affiliation:
Keywords:
Immune response, Live attenuated Y. pestis vaccines, Plague, Yersinia pestis.
Abstract: The risk of plague as a bioweapon has prompted increasing research efforts to develop plague vaccines due to
its extreme virulence and the ease of its transmission. Subunit vaccines that contain F1 and LcrV antigens of Y. pestis have
been tested for safety and immunogenicity, but doubts have been raised about whether subunit vaccines that engender antibody
responses will protect against pneumonic plague, which requires both humeral and cellular immune responses for
protection. The live, attenuated vaccine EV76, a pgm locus deficient Y. pestis strain, has been used for a long time in the
Former Soviet Union and some Asian countries, but is not commercially available in the US and Europe due to safety
concerns. However, the live attenuated Y. pestis vaccines are still considered to be the most effective way to prevent
plague. In this review, we present our opinions about rationally creating live, safe and immunogenic Y. pestis vaccines
with potential use for human based on established researches.
