Title:An Update on Autoinflammatory Diseases
Volume: 21
Issue: 3
Author(s): F. Ciccarelli, M. De Martinis and L. Ginaldi
Affiliation:
Keywords:
Auto inflammation, chronic inflammatory diseases, innate immunity.
Abstract: Autoinflammatory diseases area group of clinical conditions other than autoimmune diseases, characterized by
recurrent inflammatory episodes. From apathogenetic point of view they are determined by a dys regulation of innate immunity,
without involvement of specific immunity (auto reactive T cells and auto antibodies). Recently, the increased
knowledge in the field of auto inflammation highlighted shared immune mechanisms in the pathogenesis of both classical
monogenetic and multifactorial auto inflammatory diseases and a broad spectrum of chronic age-related inflammatory pathologies.
The current increase in the prevalence of chronic inflammatory diseases makes this subject of topical interest.
In the light of these considerations, we propose an update of auto inflammatory diseases and a new interpretation of auto
inflammation with both theoretical and clinical implications.
