Title:Pharmacology of TRP Channels in the Vasculature
Volume: 11
Issue: 4
Author(s): Isaac Jardin, Natalia Dionisio, Jose J. Lopez, Gines M. Salido and Juan A. Rosado
Affiliation:
Keywords:
TRP, smooth muscle cells, endothelial cells.
Abstract: The TRP family of cation-permeable channels owes its name to a Drosophila TRP mutant with impaired vision
due to transient rather than sustained receptor potential. Mammalian TRP channels can be grouped into 6 subfamilies, including
TRPC, TRPM, TRPV, TRPA, TRPP and TRPML and a number of TRP family members have been identified in
the vasculature. TRP channels play an important functional role in the vasculature as mediators of cation influx across the
plasma membrane, thus contributing to a large number of processes such as vascular smooth muscle contraction and vascular
pressure or the responses to oxidative stress, mechanical stimuli, heat and hypoxia-induced vascular remodelling.
TRP channelopaties are involved in the pathogenesis of different disorders including hypertension and cardiomyopathy. A
number of identified natural compounds and synthetic agents have been reported to modulate TRP function, and are the
base for therapeutical strategies.
